Reproducibility and inter-observer variability of velocity and 3D wall shear stress derived from 4D flow MRI in the healthy aorta
نویسندگان
چکیده
Background 4D flow MRI is a powerful tool to measure timeresolved three-directional blood flow in the pathological and healthy aorta. The 3D aortic velocity measured with 4D flow MRI allows for derivation of 3D wall shear stress (WSS), which is believed to be related to vessel wall remodeling and possibly an important biomarker for aortopathy. However, it is still unclear how variability of the 3D vessel segmentation needed for 3D WSS calculation and/or scan vs. rescan changes in the underlying 4D flow MRI data can affect the reproducibility of the results. The aim of this study was therefore to investigate the test-retest reproducibility and interobserver variability of 4D flow derived 3D velocity fields and 3D WSS in the thoracic aorta.
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